The EPFL Center for Brain Simulation (CBS), situated on the Campus Biotech in Geneva, Switzerland, applies advanced neuroinformatics, data analytics, high-performance computing and simulation-based approaches to the challenge of understanding the structure and function of the mammalian brain in health and disease. The CBS plays a leading role in the Human Brain Project, which aims to accelerate our understanding of the human brain, enable advances in defining and diagnosing brain disorders, and develop new brain-like technologies through open science and global collaboration.